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Dinoff A, Herrmann N, Swardfager W, Liu CS, Sherman C, Chan S, et al

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Thus, appropriate therapy for PCOS becomes necessary in order to induce ovulatory cycles and fertility ( Metformin is the most commonly used insulin-sensitizing drug to treat PCOS thanks to its ability to increase insulin sensitivity, reduce hepatic gluconeogenesis, as well as to inhibit hepatic uptake of lactate and alanine, and to increase the conversion of pyruvate to alanine